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ISO 19290:2021

Cigarettes — Determination of tobacco specific nitrosamines in mainstream cigarette smoke — Method using LC-MS/MS

General information
Valid from 03.02.2021
Directives or regulations
None
Standard history
Status
Date
Type
Name
03.02.2021
Main
28.11.2016
Main
This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
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Standard monitoring