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ISO 23921:2020

Cigarettes -- Determination of tobacco specific nitrosamines in mainstream cigarette smoke with an intense smoking regime -- Method using LC-MS/MS

General information
Valid from 30.09.2020
Directives or regulations
None
Standard history
Status
Date
Type
Name
30.09.2020
Main
This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of cigarette mainstream smoke with the intense smoking regime specified in ISO 20778 by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
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Standard monitoring